Beilstein J. Org. Chem.2018,14, 114–129, doi:10.3762/bjoc.14.7
analogues
The development of synthesis methods of nucleobase analogues remains a challenge. This is mainly due to the presence of multiple reactive functional groups both on the nucleobase as well as the sugar moiety and requires the introduction of orthogonalprotectiongroups. A careful consideration of
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Graphical Abstract
Figure 1:
a) Angles and unit vectors used to define the relative orientations of the donor and acceptor trans...
Beilstein J. Org. Chem.2012,8, 1576–1583, doi:10.3762/bjoc.8.180
; cyclic β-tripeptide scaffold; orthogonalprotectiongroups; peptide synthesis; template-assembled synthetic proteins (TASP); Introduction
Cyclic β-tripeptides form structurally well-defined secondary structures with the potential for alignment of the rings to form intermolecular aggregates [1]. Due to
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Graphical Abstract
Figure 1:
Trifunctional cyclic β-tripeptide forming an intermolecular stack of rings by backbone hydrogen bon...